The opioid epidemic refers to a serious public health problem arising from the rapid escalation of prescription and non-prescription opioid drugs. Psychiatry and Addiction World Conference (PAWC 2025) in Singapore takes center stage from June 20-22, highlighting innovative solutions for one of the most crucial global health challenges. This session focuses on the complexities of opioid addiction, including its neurobiological mechanisms, the public health impact, and the rise of synthetic opioids. Learn about cutting-edge research in precision treatment strategies, harm reduction models, and policy innovations to curb the crisis. Join leading experts as we chart new paths for tackling the opioid epidemic along with the conference theme: Future Directions in Psychiatry and Addiction Research.'